Education:
B.S. in Biochemistry with especilization in Bioinformatics, University of Havana, Cuba.
Ph.D in Biotechnology, Acharya Nagarjuna University/INDICASAT AIP.
Position:
Researcher/Core Facility PI in Bioinformatics, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP).
Research Area
- Implementation of high-performance computer systems to solve biological problems in the fields of DNA sequence analysis and structural bioinformatics.
- Genomics of pathogenic protozoan and bacterial microorganisms.
- Modelling of protein-ligand interaction applied to the design of novel vaccines and drugs.
Main research lines
- High-performance computer clusters (HPC) for the analysis of biological data.
- Interactive computer systems for the visualization of the 3D structure of biomolecules.
- Sequencing, assembly and annotation of microbial genomes with application to species of Leishmania, Leptospira y Anaplasma.
- Molecular evolution and phylogenetics applied to pathogenic microorganisms, including SARS-CoV-2 (COVID-19).
- Predictive strategies for the identification of B- and T-cell epitopes for the design of vaccines within the paradigm of reverse vaccinology.
Collaborations
- Centro de Biología Celular y Molecular de Enfermedades de INDICASAT AIP, Panama.
- Instituto Conmemorativo Gorgas de Estudios en Salud (ICGES), Panama.
- Laboratorio Nacional de Transplante de la Caja de Seguro Social (CSS), Panama.
- College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA.
- Department of Chemistry, University of Texas San Antonio, TX, USA.
Publications
First author
- Restrepo, CM, Llanes A, Herrera L., Ellis E., Lleonart R., Fernández PL (2021) Gene expression patterns associated with Leishmania panamensis infection in macrophages from BALB/c and C57BL/6 mice. PLOS Neg Trop Dis 15(2): e0009225.
- Llanes A, Ortiz L, Moscoso J, Gutierrez G, Blake E, Restrepo CM, Lleonart R, Cuero C, Vernaza-Kwiers A (2021) HLA allele and haplotype frequencies in the Panamanian population. Human Immunol 82(1):5-7.
- Llanes A, Restrepo CM, Caballero Z, Rajeev S, Kennedy MA, Lleonart R (2020) Betacoronavirus genomes: How genomic information has been used to deal with past outbreaks and the COVID-19 pandemic. Int J Mol Sci 21(12):4546.
- Llanes A, Rajeev S (2020) First whole genome sequence of Anaplasma platys, an obligate intracellular rickettsial pathogen of dogs. Pathogens 9(4):277.
- Llanes A, Restrepo CM, Lleonart R (2018) VianniaTopes: a database of predicted immunogenic peptides for Leishmania (Viannia) species. Database 2018:bay111.
- Llanes A, Restrepo CM, Riesgo-Ferreiro P, Rajeev S (2018) Genomic variability among field isolates and laboratory-adapted strains of Leptospira borgpetersenii serovar Hardjo. J. Microbiol. 2018, 2137036.
- Restrepo CM, Llanes A, De La Guardia C, Lleonart R (2015) Genome-wide discovery and development of polymorphic microsatellites from Leishmania panamensis parasites circulating in central Panama. Vectors. 8, 527.
- Llanes A, Cruz H, Nguyen VD, Larionov OV, Fernández PL (2021) A Computational Approach to Explore the Interaction of Semisynthetic Nitrogenous Heterocyclic Compounds with the SARS-CoV-2 Main Protease. Biomolecules 11(1):18.
- Herrera L, Llanes A, Álvarez J, Degracia K, Restrepo CM, Rivera R, Stephens DE, Dang HT, Larionov OL, Lleonart R, Fernández PL (2021) Antileishmanial activity of a new chloroquine analog in an animal model of Leishmania panamensis infection. Int J Parasitol Drugs Drug Resist 14:56-61.
- Llanes A, Prakoso D, Restrepo CM, Rajeev S (2020) Complete genome sequence of a virulent Leptospira interrogans serovar Copenhageni strain, assembled with a combination of Nanopore and Illumina reads. Microbiol Resour Announc 9(17):e00200-20.
- Restrepo CM, Llanes A, Cedeño EM, Chang JH, Álvarez, J, Ríos M, Penagos, H, Suárez JA, Lleonart, R (2019) Environmental conditions may shape the patterns of genomic variations in Leishmania panamensis. Genes 10(11), 838.
- González Y, Doens D, Cruz H, Santamaría R, Gutiérrez M, Llanes A, Fernández PL (2018) A Marine Diterpenoid Modulates the Proteasome Activity in Murine Macrophages Stimulated with LPS. Biomolecules 8(4), 109.
- Llanes A, Restrepo CM, Rajeev S (2016) Whole genome sequencing allows better understanding of the evolutionary history ofLeptospira interrogansserovar Hardjo. PLoS ONE 11(7), e0159387.
- Llanes A, Restrepo CM, Del Vecchio G, Anguizola FJ, Lleonart R (2015) The genome of Leishmania panamensis: insights into genomics of the (Viannia) subgenus. Sci. Rep. 5, 8550.
