Líneas de Investigación:
- Química Medicinal enfocada en la búsqueda de nuevos compuestos con potencial neuroprotector: Síntesis Orgánica, Química Computacional, Actividad Biológica y Análisis farmacéutico.
- Química de Productos Naturales: Identificación, aislamiento y evaluación biológica.
- Síntesis Orgánica
- Productos Naturales
- Modelaje Molecular
- Enfermedades Neurodegenerativas
- Análisis Farmacéutico
Logros Significativos:
Nombre de la distinción | Institución que
lo otorga |
País | Motivo | |
1 | Sistema Nacional de
Investigación |
SENACYT | Panamá | Miembro del Sistema
Nacional de Investigación |
2 | Mejor Tesis de Doctorado | Acharya Nagarjuna
University |
India | Reconocimiento a Mejor
Tesis de Doctorado |
3 | Congreso de IUBMB 2018 | International Union
Biochemistry and Molecular Biology |
Corea del Sur | Beca para participar en
Congreso de IUBMB 2018 |
4 | IUBMB 208 YSP | International Union
Biochemistry and Molecular Biology |
Corea del Sur | Beca para participar en
IUBMB 2018 YSP
|
5 | IBRO LARC Short stay
Grants Program |
International Brain
Research Organization |
Colombia | Estadía Corta para estar
en Colombia |
6 | 15th ISN Advanced School of Neurochemistry in conjunction with the ISN-ASN 2019 Meeting. | ISN-ASN 2019 | Canada | Beca para participar en
ISN-ASN 2019 Meeting.
|
7 | 7th Conference of the
Mediterranean Neuroscience Society |
MNS 209 | Marruecos | Beca para participar en
Mediterranean Neuroscience Society |
8 | Becaria de SENACYT-IFARHU | Realizar el Doctorado en
Biotecnología |
India/Panamá | |
9 | Graduación de Honor en
la Maestría en Química |
Universidad de
Costa Rica |
Costa Rica | Graduación de Honor en
la Maestría en Química |
10 | Becaria del Servicio de Intercambio Aleman (DAAD) | Realizar la Maestría en
Química Orgánica |
Costa Rica |
Resumen de la hoja de vida:
1 | Investigadora | INDICASAT AIP | Panamá |
2 | Estancia Post-Doctoral en la Universidad de Texas en
San Antonio |
University of Texas at San Antonio | Estados Unidos |
3 | Estancia Post-Doctoral en la Universidad Nacional de
Colombia |
Universidad Nacional de Colombia
|
Colombia |
4 | Post-Doctorado en INDICASAT AIP | INDICASAT AIP | Panamá |
5 | Doctorado en Biotecnología | Acharya Nagarjuna University | India |
6 | Estancia Doctoral en la Universidad de Texas en San
Antonio |
University of Texas at San Antonio | Estados Unidos |
7 | Estancia Doctoral en la Universidad Medica de Carolina
del Sur |
Medical University of South Caroline | Estados Unidos |
8 | Especialista en Docencia Superior | Universidad de Panamá | Panamá |
9 | Profesora de Educación Media con
Especialización en Química |
Universidad de Panamá | Panamá |
10 | Maestría en Química | Universidad de Costa Rica | Costa Rica |
11 | Licenciatura en Química | Universidad de Panamá | Panamá |
Publicaciones seleccionadas:
González, Yisett, Randy Mojica-Flores, Dilan Moreno-Labrador, Luis Cubilla-Rios, K. S.Jagannatha Rao, Patricia L. Fernández, Oleg V. Larionov, and Johant Lakey-Beitia. “Polyphenols with Anti-Inflammatory Properties: Synthesis and Biological Activity of Novel Curcumin Derivatives.” International Journal of Molecular Sciences 24 (4): 3691. https://doi.org/10.3390/ijms24043691.
González, Yisett, Randy Mojica-Flores, Dilan Moreno-Labrador, Marisín Pecchio, K. S.Jagannatha Rao, Maicol Ahumedo-Monterrosa, Patricia L. Fernández, Oleg V. Larionov, and Johant Lakey-Beitia. 2023. “Tetrahydrocurcumin Derivatives Enhanced the Anti-Inflammatory Activity of Curcumin: Synthesis, Biological Evaluation, and Structure–Activity Relationship Analysis.” Molecules 28 (23). https://doi.org/10.3390/molecules28237787.
Lakey-Beitia, Johant, Velmarini Vasquez, Randy Mojica-Flores, Arelys L. Fuentes C., Enrique Murillo, Muralidhar L. Hedge, and K.S. Rao. 2021. “Pouteria Sapota (Red Mamey Fruit): Chemistry and Biological Activity of Carotenoids.” Combinatorial Chemistry & High Throughput Screening. https://doi.org/10.2174/1386207324666210301093711.
Ikewaki, Nobunao, Masaru Iwasaki, Gene Kurosawa, Kosagi-Sharaf Rao, Johant Lakey-Beitia, Senthilkumar Preethy, and Samuel JK Abraham. 2021. “β-Glucans: Wide-Spectrum Immune-Balancing Food-Supplement-Based Enteric (β-WIFE) Vaccine Adjuvant Approach to COVID-19.” Human Vaccines & Immunotherapeutics. https://doi.org/10.1080/21645515.2021.1880210.
Orjuela, Adrian, Johant Lakey-Beitia, Randy Mojica-Flores, Muralidhar L. Hegde, Isaias Lans, Jorge Alí-Torres, and K. S. Rao. 2021. “Computational Evaluation of Interaction between Curcumin Derivatives and Amyloid-βMonomers and Fibrils: Relevance to Alzheimer’s Disease.” Journal of Alzheimer’s Disease 82 (s1): S321–33. https://doi.org/10.3233/JAD-200941.
Aron, Allegra T., Emily C. Gentry, Kerry L. McPhail, Louis Félix Nothias, Mélissa Nothias-Esposito, Amina Bouslimani, Daniel Petras, et al. 2020. “Reproducible Molecular Networking of Untargeted Mass Spectrometry Data Using GNPS.” Nature Protocols 15 (6): 1954–91. https://doi.org/10.1038/s41596-020-0317-5.
Murillo, Enrique, Attila Agócs, Veronika Nagy, Sándor Balázs Király, Tibor Kurtán, Eunice Molinar Toribio, Johant Lakey-Beitia, and József Deli. 2020. “Isolation and Identification of Sapotexanthin 5,6-Epoxide and 5,8-Epoxide from Red Mamey (Pouteria Sapota).” Chirality 32 (5): 579–87. https://doi.org/10.1002/chir.23206.
Nami, Mohammad, Samrad Mehrabi, Ali Mohammad Kamali, Milad Kazemiha, Jose Carvalho, Sabri Derman, Johant Lakey-Betia, Velmarini Vasquez, and Rao Kosagisharaf. 2020. “A New Hypothesis on Anxiety, Sleep Insufficiency, and Viral Infections; Reciprocal Links to Consider in Today’s ‘World vs. COVID-19’ Endeavors.” Frontiers in Psychiatry. https://doi.org/10.3389/fpsyt.2020.585893.
Lakey-Beitia, Johant, Andrea M. Burillo, Giovanni La Penna, Muralidhar L. Hegde, and K.S. Rao. 2020. “Polyphenols as Potential Metal Chelation Compounds Against Alzheimer’s Disease.” Journal of Alzheimer’s Disease 2020: 1–23. https://doi.org/10.3233/jad-200185.
Lakey-Beitia, Johant, Jagadeesh Kumar D., Muralidhar L Hegde, and K.S. Rao. 2019. “Carotenoids as Novel Therapeutic Molecules Against Neurodegenerative Disorders: Chemistry and Molecular Docking Analysis.” International Journal of Molecular Sciences 20 (5553): 1–22. https://doi.org/10.3390/ijms20225553.
Lakey-Beitia, Johant, Patricia Llanes, Oleg Larionov, Armando Durant, and K.S Jagannatha Rao. 2019. “MTU03-17 Novel Curcumin Derivatives and Carotenoids as Inhibitors of Amyloid-B Aggregation and Inflammation in Alzheimer’s Drug Discovery.” J Neurochem 150 (S1): 85–86. https://doi.org/10.1111/jnc.14776.
Lakey-Beitia, Johant, Deborah Doens, D. Jagadeesh Kumar, Enrique Murillo, Patricia L. Fernández, KS Rao, and Armando A. Durant-Archibold. 2017. “Anti-Amyloid Aggregation Activity of Novel Carotenoids: Implications for Alzheimer’s Drug Discovery.” Clinical Interventions in Aging 12 (May): 815–22. https://doi.org/10.2147/CIA.S134605.
Lakey-Beitia, Johant, Yisett Gonzalez, Deborah Doens, David E. Stephens, Ricardo Santamaria, Enrique Murillo, Marcelino Gutierrez, et al. 2017. “Assessment of Novel Curcumin Derivatives as Potent Inhibitors of Inflammation and Amyloid-Beta Aggregation in Alzheimer Disease.” J Alzheimers Dis 2017 (2017): 1–10. https://doi.org/10.3233/JAD-170071.
Stephens, David E., Johant Lakey-Beitia, Jessica E. Burch, Hadi D. Arman, and Oleg V. Larionov. 2016. “Mechanistic Insights into the Potassium Tert-Butoxide-Mediated Synthesis of N-Heterobiaryls.” Commun52: 9945–48. https://doi.org/10.1039/b000000x.
Stephens, David E., Johant Lakey-Beitia, Gabriel Chavez, Carla Ilie, Hadi D. Arman, and Oleg V. Larionov. 2015. “Experimental and Mechanistic Analysis of the Palladium- Catalyzed Oxidative C8-Selective C–H Homocoupling of Quinoline N-Oxides.” Chem Commun 51 (46): 9507–10. https://doi.org/10.1016/j.physbeh.2017.03.040.
Stephens, David E., Johant Lakey-Beitia, Abdurrahman C. Atesin, Tülay A. Ateşin, Gabriel Chavez, Hadi D. Arman, and Oleg V. Larionov. 2015. “Palladium-Catalyzed C8-Selective C–H Arylation of Quinoline N -Oxides: Insights into the Electronic, Steric, and Solvation Effects on the Site Selectivity by Mechanistic and DFT Computational Studies.” ACS Catalysis 5: 167–75. https://doi.org/10.1021/cs501813v.
Lakey-Beitia, Johant, Ruben Berrocal, K. S. Rao, and Armando A. Durant. 2015. “Polyphenols as Therapeutic Molecules in Alzheimer’s Disease Through Modulating Amyloid Pathways.” Molecular Neurobiology 51 (2): 466–79. https://doi.org/10.1007/s12035-014-8722-9.
Lakey-Beitia, Johant Lizel. 2011. “Tripotassium Phosphate: From Buffers to Organic Synthesis.” Synlett, no. 1: 139–40. https://doi.org/10.1055/s-0030-1259092.
Proyectos Actuales
Investigación o estudio
|
Año |
Financiamiento (fuente, monto)
|
|
1 | Síntesis Orgánica, Modelaje Molecular y Evaluación Biológica de novedosos derivados de Naringenina frente a la alfa-Sinucleina. | 2023 | SENACYT (B/. 70,000) |
2 | Estudios de Actividad Biológica de Novedosos Derivados Sintéticos de Curcumina y Tetrahidrocurcumina con Potencial Anti-Cancerígeno | 2023 | SENACYT (B/. 70,000) |
3 | Taller Sobre los Avances en Ciencia, Tecnología e Inovación para Profesores de Ciencia de Educación Media de Darién | 2019 | SENACYT (B/. 10,000) |
4 | Síntesis y Elucidación Estructural de la Nueva Familia de Curcuxanthinoides con Potencial Actividad Neuroprotectora | 2018 | SENACYT (B/.10,000) |
5 | Química Computacional y Modelaje molecular Aplicado al Diseño de Drogas | 2018 | SENACYT (B/.20,000) |
6 | Síntesis, Modelaje Molecular y Actividad Biológica de Novedosos Derivados de Curcumina y Tetrahidrocurcumina Contra la Enfermedad de Parkinson. | 2017 | SENACYT (B/.120,000) |
7 | Síntesis de Derivados de Carotenoides frente a la
Enfermedad de Alzheimer |
2017 | Melo Grant (B/.50,000) |

Dra. Johant Lakey Beitia
Máximo grado de estudios:
Categoría: Investigador, Centro de Biodiversidad y Descubrimiento de Drogas