Publicaciones seleccionadas

Publicaciones:

Almaliti, J., Malloy, K. L., Glukhov, E., Spadafora, C., Gutiérrez, M., & Gerwick, W. H. (2017). Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens. Journal of Natural Products, 80(6), 1827–1836. https://doi.org/10.1021/acs.jnatprod.7b00034

Aron, A. T., Gentry, E. C., McPhail, K. L., Nothias, L. F., Nothias-Esposito, M., Bouslimani, A., Petras, D., Gauglitz, J. M., Sikora, N., Vargas, F., van der Hooft, J. J. J., Ernst, M., Kang, K. Bin, Aceves, C. M., Caraballo-Rodríguez, A. M., Koester, I., Weldon, K. C., Bertrand, S., Roullier, C., … Dorrestein, P. C. (2020). Reproducible molecular networking of untargeted mass spectrometry data using GNPS. Nature Protocols, 15(6), 1954–1991. https://doi.org/10.1038/s41596-020-0317-5

Atencio, L. A., Boya, C. A. P., Christian Martin, H., Mejía, L. C., Dorrestein, P. C., & Gutiérrez, M. (2020). Genome mining, microbial interactions, and molecular networking reveals new dibromoalterochromides from strains of pseudoalteromonas of coiba national park-panama. Marine Drugs, 18(9). https://doi.org/10.3390/md18090456

Atencio, L. A., Dal Grande, F., Young, G. O., Gavilán, R., Guzmán, H. M., Schmitt, I., Mejía, L. C., & Gutiérrez, M. (2018). Antimicrobial-producing Pseudoalteromonas from the marine environment of Panama shows a high phylogenetic diversity and clonal structure. Journal of Basic Microbiology, 58(9), 747–769. https://doi.org/10.1002/jobm.201800087

Gutiérrez, M., Tidgewell, K., Capson, T. L., Engene, N., Almanza, A., Schemies, J., Jung, M., & Gerwick, W. H. (2010). Malyngolide dimer, a bioactive symmetric cyclodepside from the panamanian marine cyanobacterium lyngbya majuscula. Journal of Natural Products, 73(4), 709–711. https://doi.org/10.1021/np9005184

Gutiérrez G, M., Watson-Samudio, H., Vega A, E. y Cubilla R, L. (2005) Rotenoides bioactivos de la raíz de Lonchocarpus pentaphyllus, Tecnociencia, 7(1), 81-88.

Lakey-Beitia, J., González, Y., Doens, D., Stephens, D. E., Santamaría, R., Murillo, E., Gutiérrez, M., Fernández, P. L., Rao, K. S., Larionov, O. V., & Durant-Archibold, A. A. (2017). Assessment of Novel Curcumin Derivatives as Potent Inhibitors of Inflammation and Amyloid-β Aggregation in Alzheimer’s Disease. In Journal of Alzheimer’s Disease (Vol. 60, Issue s1, pp. S59–S68). IOS Press. https://doi.org/10.3233/JAD-170071

Liu, W. T., Ng, J., Meluzzi, D., Bandeira, N., Gutierrez, M., Simmons, T. L., Schultz, A. W., Linington, R. G., Moore, B. S., Gerwick, W. H., Pevzner, P. A., & Dorrestein, P. C. (2009). Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. Analytical Chemistry, 81(11), 4200–4209. https://doi.org/10.1021/ac900114t

Boya, C. A., Fernández-Marín, H., Mejiá, L. C., Spadafora, C., Dorrestein, P. C., & Gutiérrez, M. (2017). Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-05515-6

Boya, C. A., Herrera, L., Guzman, H. M., & Gutierrez, M. (2012). Antiplasmodial activity of bacilosarcin A isolated from the octocoral-associated bacterium Bacillus sp. collected in Panama. Journal of Pharmacy and Bioallied Sciences, 4(1), 66–69. https://doi.org/10.4103/0975-7406.92739

Boya P, C. A., Christian, M. H., Fernandez-Marin, H., & Gutierrez, M. (2019). Fungus-growing ant’s microbial interaction of streptomyces sp. and escovopsis sp. through molecular networking and MALDI imaging. Natural Product Communications, 14(1), 63–66. https://doi.org/10.1177/1934578X1901400117

Christian, M. H., Ibáñez, R., Nothias, L. F., Caraballo-Rodríguez, A. M., Dorrestein, P. C., & Gutiérrez, M. (2020). Metabolites from microbes isolated from the skin of the panamanian rocket frog colostethus panamansis (Anura: Dendrobatidae). Metabolites, 10(10), 1–19. https://doi.org/10.3390/metabo10100406

Martin H, C., Ibáñez, R., Nothias, L. F., Boya P, C. A., Reinert, L. K., Rollins-Smith, L. A., Dorrestein, P. C., & Gutiérrez, M. (2019). Viscosin-like lipopeptides from frog skin bacteria inhibit Aspergillus fumigatus and Batrachochytrium dendrobatidis detected by imaging mass spectrometry and molecular networking. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-019-39583-7

Martínez-Luis, S., Cherigo, L., Spadafora, C., & Gutiérrez, M. (2019). Antiparasitic compounds from the panamanian marine bacterium pseudomonas aeruginosa. Natural Product Communications, 14(1), 31–32. https://doi.org/10.1177/1934578X1901400109

Martínez-Luis, S., Gómez, J. F., Spadafora, C., Guzmán, H. M., & Gutiérrez, M. (2012). Antitrypanosomal alkaloids from the marine bacterium Bacillus pumilus. Molecules, 17(9), 11146–11155. https://doi.org/10.3390/molecules170911146

Moree, W. J., McConnell, O. J., Nguyen, D. D., Sanchez, L. M., Yang, Y. L., Zhao, X., Liu, W. T., Boudreau, P. D., Srinivasan, J., Atencio, L., Ballesteros, J., Gavilán, R. G., Torres-Mendoza, D., Guzmán, H. M., Gerwick, W. H., Gutiérrez, M., & Dorrestein, P. C. (2014). Microbiota of healthy corals are active against fungi in a light-dependent manner. ACS Chemical Biology, 9(10), 2300–2308. https://doi.org/10.1021/cb500432j

Garrido, A., Atencio, L. A., Bethancourt, R., Bethancourt, A., Guzmán, H., Gutiérrez, M., & Durant-Archibold, A. A. (2020). Antibacterial activity of volatile organic compounds produced by the octocoral-associated bacteria bacillus sp. Bo53 and pseudoalteromonas sp. ga327. Antibiotics, 9(12), 1–10. https://doi.org/10.3390/antibiotics9120923

Gómez-Reyes, J. F., Salazar, A., Guzmán, H. M., González, Y., Fernández, P. L., Ariza-Castolo, A., & Gutiérrez, M. (2012). seco-briarellinone and briarellin S, two new eunicellin-based diterpenoids from the panamanian octocoral Briareum asbestinum. Marine Drugs, 10(11), 2608–2617. https://doi.org/10.3390/md10112608

González, Y., Doens, D., Cruz, H., Santamaría, R., Gutiérrez, M., Llanes, A., & Fernández, P. L. (2018). A marine diterpenoid modulates the proteasome activity in murine macrophages stimulated with LPS. Biomolecules, 8(4). https://doi.org/10.3390/biom8040109

González, Y., Doens, D., Santamaría, R., Ramos, M., Restrepo, C. M., Barros De Arruda, L., Lleonart, R., Gutiérrez, M., & Fernández, P. L. (2013). A pseudopterane diterpene isolated from the octocoral Pseudopterogorgia acerosa inhibits the inflammatory response mediated by TLR-ligands and TNF-alpha in macrophages. PLoS ONE, 8(12). https://doi.org/10.1371/journal.pone.0084107

Moree, W. J., Yang, J. Y., Zhao, X., Liu, W. T., Aparicio, M., Atencio, L., Ballesteros, J., Sánchez, J., Gavilán, R. G., Gutiérrez, M., & Dorrestein, P. C. (2013). Imaging Mass Spectrometry of a Coral Microbe Interaction with Fungi. Journal of Chemical Ecology, 39(7), 1045–1054. https://doi.org/10.1007/s10886-013-0320-1

Nguyen, D. D., Wu, C. H., Moree, W. J., Lamsa, A., Medema, M. H., Zhao, X., Gavilan, R. G., Aparicio, M., Atencio, L., Jackson, C., Ballesteros, J., Sanchez, J., Watrous, J. D., Phelan, V. V., Van De Wiel, C., Kersten, R. D., Mehnaz, S., De Mot, R., Shank, E. A., … Dorrestein, P. C. (2013). MS/MS networking guided analysis of molecule and gene cluster families. Proceedings of the National Academy of Sciences of the United States of America, 110(28). https://doi.org/10.1073/pnas.1303471110

Rodriguez, C., Ibáñez, R., Ng, M., Spadafora, C., Durant-Archibold, A. A., & Gutiérrez, M. (2020). 19-Hydroxy-bufalin, a major bufadienolide isolated from the parotoid gland secretions of the Panamanian endemic toad Rhinella centralis (Bufonidae), inhibits the growth of Trypanosoma cruzi. Toxicon, 177, 89–92. https://doi.org/10.1016/j.toxicon.2020.02.009

Gutiérrez, M., Andrianasolo, E. H., Shin, W. K., Goeger, D. E., Yokochi, A., Schemies, J., Jung, M., France, D., Cornell-Kennon, S., Lee, E., & Gerwick, W. H. (2009). Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula. Journal of Organic Chemistry, 74(15), 5267–5275. https://doi.org/10.1021/jo900578j

Gutiérrez, M., Capson, T. L., Guzmán, H. M., González, J., Ortega-Barría, E., Quiñoá, E., & Riguera, R. (2006). Antiplasmodial metabolites isolated from the marine octocoral Muricea austera. Journal of Natural Products, 69(10), 1379–1383. https://doi.org/10.1021/np060007f

Gutiérrez, M., Capson, T. L., Guzmán, H. M., González, J., Ortega-Barría, E., Quiñoá, E., & Riguera, R. (2005). Antiprotozoal activity against Plasmodium falciparum and Trypanosoma cruzi of aeroplysinin-1 isolated from the new sponge Aplysina chiriquensis. Pharmaceutical Biology, 43(9), 762–765. https://doi.org/10.1080/13880200500406503

Gutiérrez, M., Capson, T. L., Guzmán, H. M., González, J., Ortega-Barría, E., Quiñoá, E., & Riguera, R. (2005). Leptolide, a new furanocembranolide diterpene from Leptogorgia alba. Journal of Natural Products, 68(4), 614–616. https://doi.org/10.1021/np049745z

Rodriguez, C., Ibáñez, R., Rollins-Smith, L. A., Gutiérrez, M., & Durant-Archibold, A. A. (2020). Antimicrobial secretions of toads (Anura, bufonidae): Bioactive extracts and isolated compounds against human pathogens. In Antibiotics (Vol. 9, Issue 12, pp. 1–15). MDPI AG.https://doi.org/10.3390/antibiotics9120843

Rodríguez, C., Rollins-Smith, L., Ibáñez, R., Durant-Archibold, A. A., & Gutiérrez, M. (2017). Toxins and pharmacologically active compounds from species of the family Bufonidae (Amphibia, Anura). In Journal of Ethnopharmacology (Vol. 198, pp. 235–254). Elsevier Ireland Ltd. https://doi.org/10.1016/j.jep.2016.12.021

Tayler, N. M., Boya, C. A., Herrera, L., Moy, J., Ng, M., Pineda, L., Almanza, A., Rosero, S., Coronado, L. M., Correa, R., Santamaría, R., Caballero, Z., Durant-Archibold, A. A., Tidgewell, K. J., Balunas, M. J., Gerwick, W. H., Spadafora, A., Gutiérrez, M., & Spadafora, C. (2019). Analysis of the antiparasitic and anticancer activity of the coconut palm (Cocos nucifera L. ARECACEAE) from the natural reserve of Punta Patiño, Darién. PLoS ONE, 14(4). https://doi.org/10.1371/journal.pone.0214193

Gutiérrez, M., Capson, T., Guzmán, H. M., Quiñoá, E., & Riguera, R. (2004). L-Galactose as a natural product: Isolation from a marine octocoral of the first α-L-galactosyl saponin. Tetrahedron Letters, 45(42), 7833–7836. https://doi.org/10.1016/j.tetlet.2004.08.170

Gutiérrez, M., Santamaría, R., Gómez-Reyes, J. F., Guzmán, H. M., Ávila-Román, J., Motilva, V., & Talero, E. (2020). New eunicellin-type diterpenes from the Panamanian octocoral Briareum asbestinum. Marine Drugs, 18(2). https://doi.org/10.3390/md18020084

Gutiérrez, M., Suyama, T. L., Engene, N., Wingerd, J. S., Matainaho, T., & Gerwick, W. H. (2008). Apratoxin D, a potent cytotoxic cyclodepsipeptide from papua new Guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida. Journal of Natural Products, 71(6), 1099–1103. https://doi.org/10.1021/np800121a

Gutiérrez, M., Pereira, A. R., Debonsi, H. M., Ligresti, A., Di Marzo, V., & Gerwick, W. H. (2011). Cannabinomimetic lipid from a marine cyanobacterium. Journal of Natural Products, 74(10), 2313–2317. https://doi.org/10.1021/np200610t

Torres-Mendoza, D., González, Y., Gómez-Reyes, J. F., Guzmán, H. M., López-Perez, J. L., Gerwick, W. H., Fernandez, P. L., & Gutiérrez, M. (2016). Uprolides N, O and P from the Panamanian octocoral Eunicea succinea. Molecules, 21(6). https://doi.org/10.3390/molecules21060819

Torres-Mendoza, D., Coronado, L. M., Pineda, L. M., Guzmán, H. M., Dorrestein, P. C., Spadafora, C., & Gutiérrez, M. (2018). Pumilacidins from the octocoral-associated bacillus sp. Dt001 display anti-proliferative effects in plasmodium falciparum. Molecules, 23(9). https://doi.org/10.3390/molecules23092179

Wang, M., Carver, J. J., Phelan, V. V., Sanchez, L. M., Garg, N., Peng, Y., Nguyen, D. D., Watrous, J., Kapono, C. A., Luzzatto-Knaan, T., Porto, C., Bouslimani, A., Melnik, A. V., Meehan, M. J., Liu, W. T., Crüsemann, M., Boudreau, P. D., Esquenazi, E., Sandoval-Calderón, M., … Bandeira, N. (2016). Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. In Nature Biotechnology (Vol. 34, Issue 8, pp. 828–837). Nature Publishing Group. https://doi.org/10.1038/nbt.3597